Chiarle Lab

Immagine logo Università di Torino

The Chiarle Lab in Torino is focused on understanding the oncogenic signaling in cancers, with particular interest in targeted therapies, immunotherapies and resistance. Cancers studied include Lymphoma, non-small cell lung cancer (NSCLC) and neuroblastoma. Our main approach is to study the role of specific oncogenes in cancer development and therapy. We have extensively studied the role of ALK in lymphoma by discovering multiple pathways exploited to induce cellular transformation. By exploiting cell line xenografts, patient-derived xenografts and organoids, as well as mouse models for lymphoma and NSCLC, and neuroblastoma, we aim at defining relevant mechanisms of ALK-mediated transformation in vivo but also to validate therapeutic approaches to target ALK. The ambitious but clear goal of the Chiarle Lab is to find a cure for ALK-driven cancers. This approach will be eventually extended to other types of cancers.

Research

Among disease-defining translocation in lymphoma, the translocations involving the Anaplastic Lymphoma Kinase (ALK) gene are characteristic of Anaplastic Large Cell Lymphoma (ALCL), but were recently found also in Non-Small Cell Lung Cancers (NSCLC) and other type of solid tumors. We have extensively studied the role of ALK in lymphoma by discovering multiple pathways exploited to induce cellular transformation.
Ambitiously, the ChiarleLab wants to find the definitive cure for ALK-driven cancers.
By exploiting cell line xenografts, patient-derived xenografts and organoids, as well as mouse models for lymphoma and NSCLC, and neuroblastoma, our goal is to discover the key mechanisms of ALK-mediated transformation and resistance to therapy while developing therapeutic approaches to completely eradicate ALK-positive cancers. To this end, we will combine innovative therapies such as ALK inhibitors and a portfolio of ALK-specific immunotherapies, that include ALK vaccines, ALK-specific CAR T cells and ALK-specific TCR T cells.

Our team

Immagine di Roberto Chiarle

Roberto Chiarle

Immagine di Claudia Voena

Claudia Voena

PhD

Immagine di Cristina Mastini

Cristina Mastini

PhD

Immagine di Marta Rubin

Marta Rubin

Phd Student

Immagine di Mariapia Russo

Mariapia Russo

PhD Student

Immagine di Giulia Mura

Giulia Mura

MS

Immagine di Maria Vittoria Dimarco

Maria Vittoria Dimarco

PhD Student

Immagine di Andrea Macioce

Andrea Macioce

MS

Immagine di Martina Maggiore

Martina Maggiore

MS

Immagine di Dominik Cande

Dominik Candea

PhD Student

Immagine di Monica Maccagno

Monica Maccagno

PhD Student

Former member

Immagine di Enrico Patrucco

ENRICO PATRUCCO

PhD

Immagine di Chiara Pighi

CHIARA PIGHI

Immagine di Serena Germani

SERENA GERMANI

Immagine di Cristina Mastini

Cristina Mastini

Immagine di Valerio

Valerio

Immagine di Roberta Pulito

Roberta Pulito

Immagine di Silvia Peola

Silvia Peola

Immagine di Matteo Menotti

Matteo Menotti

Immagine di Teresa Poggio

Teresa Poggio

Immagine di Ramesh. C. Choudhari

Ramesh. C. Choudhari

Immagine di Scalzo Maria Stella

Scalzo Maria Stella

Immagine di Lydia Varesio

Lydia Varesio

Immagine di Maria Elena Boggio Merlo

Maria Elena Boggio Merlo

Our sponsor

International projects

Immagine logo Alkatras

International collaborative project with Alkatras

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Immagine logo Fantom

International collaborative project with Fantom

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International collaborative project (2018-2020) with the Shanghai Jiao Tong University supported by the Ministero degli Affari Esteri e della Cooperazione Internazionale (MAECI).

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Contact

ROBERTO CHIARLE, M.D.

Professor of Pathology
University of Torino
Piazza Nizza 44Bis, 10126 Torino, ITALY
Dept. of Molecular Biotechnology and Health Sciences
Phone: +39 0116706568
Office: +39 011 6708444
roberto.chiarle@unito.it

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