Chiarle Lab

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Our projects

ELUCIDATION OF BASIC PRINCIPLES THAT GOVERN CHROMOSOMAL TRANSLOCATION FORMATION IN NORMAL AND NEOPLASTIC CELLS

We contributed to the development of a method to comprehensively map translocations at a genome-wide level. By leveraging this method called High-Throughput Genome-wide Translocation Sequencing (HTGTS) we began a series of studies aimed at defining general rules for translocation formation, focusing on how transcription, DNA Double Strand Breaks (DBSs), tissue specificity and other nuclear or DNA repair factors can influence the type and the frequency of translocations found in human cancers.

STUDY OF TUMORS DRIVEN BY ONCOGENIC ALTERATIONS OF THE ANAPLASTIC LYMPHOMA KINASE (ALK) GENE

As translocations and activation mutations that are characteristic of Anaplastic Large Cell Lymphoma (ALCL), Non-Small Cell Lung Cancers (NSCLC) and other type of solid tumors including neuroblastoma. We have extensively studied the role of ALK in lymphoma and in lung cancer by discovering multiple pathways exploited to induce cellular transformation. We are currently implementing innovative therapies such as ALK inhibitors and ALK-specific cancer immunotherapy. We developed an ALK vaccine that generates strong and specific immune responses against tumors cells that express ALK as an oncogenic driver. We are also developing ALK-specific chimeric antigen receptor (CAR) T cells to target tumors that express ALK on their surface, such as neuroblastoma.

DISCOVERY AND VALIDATE NOVEL MECHANISMS OF RESISTANCE TO TARGETED THERAPY IN LYMPHOMA AND SOLID CANCERS

Our team

Immagine di Roberto Chiarle

Roberto Chiarle

Immagine di Qi Wang

QI WANG

PHD

Immagine di Taek-Chin Cheong

TAEK-CHIN CHEONG

PHD

Immagine di Jianli Tao

JIANLI TAO

PHD

Immagine di Elisa Bergaggio

ELISA BERGAGGIO

PHD

Immagine di Marco Campisi

MARCO CAMPISI

PHD

Immagine di Carmen Mecca

CARMEN MECCA

PHD

Immagine di Luca Alessandri

LUCA ALESSANDRI

PHD

Immagine di Alessandro Gasparetto

ALESSANDRO GASPARETTO

MD

Immagine di Alessandra Camboni

ALESSANDRA CAMBONI

MD

Immagine di Haley Ohlson

HALEY OHLSON

MS

Immagine di Simone Piane

SIMONE PIANE

MD

Immagine di Gabriele Saccu

GABRIELE SACCU

PHD

Former member

Immagine di Rafael Blasco-Patino

Rafael Blasco-Patiño

PhD

Immagine di Jasna Metovic

Jasna Metovic

PhD STUDENT

Immagine di Elena Vissio

Elena Vissio

PhD STUDENT

Immagine di Andrea Aroldi

Andrea Aroldi

MD

Immagine di Giulia Leonardi

Giulia Leonardi

MD, PhD

Immagine di Ines Mota

Ines Mota

PhD

Immagine di Elif Karaca

Elif Karaca

PhD

Immagine di Wei-Tien Tai

Wei-Tien Tai

PhD

Immagine di Caspian Harding

Caspian Harding

Immagine di Serena Stadler

Serena Stadler

PhD

Immagine di Manuel Nuesch

Manuel Nuesch

Immagine di Chiara Pighi

Chiara Pighi

PhD

Immagine di Sylvie Giuriato

Sylvie Giuriato

PhD

Immagine di Domenico Sorrentino

Domenico Sorrentino

PhD

Immagine di Mara Compagno

Mara Compagno

PhD

Immagine di Claudia Voena

Claudia Voena

PhD

Immagine di Fernanda Langellotto

Fernanda Langellotto

PhD

Immagine di Teresa Poggio

Teresa Poggio

PhD

Immagine di Dylan Mooijman

Dylan Mooijman

PhD

Immagine di Emre Karayol

Emre Karayol

MD

Immagine di Cinzia Martinengo, PhD

Cinzia Martinengo

PhD

Our sponsors

Contact

ROBERTO CHIARLE, M.D.

Professor
Department of Pathology
Children's Hospital Boston
Harvard Medical School
Enders 1174.1
300 Longwood Ave
Boston, MA 02115
Phone: +1 (617) 919-2662
roberto.chiarle@childrens.harvard.edu

SUSAN WONG

Administrative Assistant
Department of Pathology
Children's Hospital Boston
Harvard Medical School
Enders 1170
300 Longwood Ave
Boston, MA 02115
susan.wong@childrens.harvard.edu

ANTHONY CALDERONE

Program Coordinator
Department of Pathology
Children's Hospital Boston
Harvard Medical School
300 Longwood Avenue
Bader Building, BA-138
Boston, MA 02115
Phone: +1 (617) 355-8969
anthony.calderone@childrens.harvard.edu

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